Substitution at R3 using a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency with the halide analogs (74g–h) demonstrating optimum the potency from the group. Even further optimization triggered the discovery of 74i–j, with 74k as essentially the most active compound during the sequence (pIC50 https://garrettharrh.blogvivi.com/32025321/a-review-of-indazole-carboxamide