Substitution at R3 that has a halogen or alkoxy group (74f–74i) brought about a slight increase in mobile potency While using the halide analogs (74g–h) exhibiting highest the potency in the group. Further optimization brought about the discovery of 74i–j, with 74k as one of the most active compound in https://indazole-products10864.digitollblog.com/31250257/5-essential-elements-for-indazole-drugs