Opioid action is because of equally very low affinity binding on the guardian compound and better affinity binding with the O-demethylated metabolite M1 to μ-opioid receptors. In animal designs, M1 is approximately 6 times extra powerful than tramadol in manufacturing analgesia and 200 periods much more strong in μ-opioid binding. https://paulf751chh5.blogpixi.com/profile