Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have discovered recurrent mutations in genes regulating tumor cell-microenvironment interac... https://chrisx715rzd5.mdkblog.com/profile