If a guardian of your proband is known to have the pathogenic variant identified during the proband, the chance to your sibs of inheriting the pathogenic variant is 50%. Because of diminished penetrance, sibs who inherit the pathogenic variant may or may not develop aHUS (see Penetrance). The Trane variety https://ahu-hire10976.worldblogged.com/37774019/air-handling-units-ahus-no-further-a-mystery