Comment: Barbiturates may enhance adverse effects, such as respiratory melancholy, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs. pentobarbital will lower the level or result of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known. Wit... https://edithb221tkz0.blog-mall.com/profile