Hedgehog (HH) signaling is important for embryonic pattering and stem cell differentiation. The G protein-coupled receptor (GPCR) Smoothened (SMO) is the key HH signal transducer modulating both transcription-dependent and transcription-independent responses. We show that SMO protects naive mouse embryonic stem cells (ESCs) from dissociation-induced cell death. https://www.ivoryjinelle.com/top-offer-Dragon-Ball-Super-Goku-Vegeta-Super-Ball-LG-Stylo-6-Clear-Case-p103191-quick-deal/