There exists a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to decrease afferent soreness transmission and create analgesia. As a result, drugs like clonidine that concentrate on alpha-two receptors can impact the transmission of pain. : linked to, served https://www.proleviate.com/post/the-new-pain-killer-conolidine